3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde → HCID 11998933、化合物
反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(O[C:17](=O)[NH:18][C@@H:19]1[CH2:24][CH2:23][C@@H:22]([CH:25]=[O:26])[O:21][CH2:20]1)(C)(C)C.[O:28]=[C:29]1[CH2:34][S:33][C:32]2[CH:35]=[CH:36][C:37](C=O)=[N:38][C:31]=2[NH:30]1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([C:25]([C@H:22]3[O:21][CH2:20][C@H:19]([NH:18][CH2:17][C:37]4[CH:36]=[CH:35][C:32]5[S:33][CH2:34][C:29](=[O:28])[NH:30][C:31]=5[N:38]=4)[CH2:24][CH2:23]3)=[O:26])[S:11][C:7]=2[CH:6]=[CH:5][CH:4]=1参加物
4
実験手順
Using the same method as for Example 23, steps 23.a to 23.f, the title compound was synthesised from 4-methoxybenzothiazole, (3R,6S)-(6-formyl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde. After chromatography on SiO2 (EtOAc/MeOH 9:1 +1% NH4OH) and crystallisation from ether/MeOH, a yellowish solid (30 mg) was obtained.
後処理
- customAfter chromatography on SiO2 (EtOAc/MeOH 9:1 +1% NH4OH) and crystallisation from ether/MeOH
出典と根拠
- ORDレコード
- ord-1dc32f683a7a420a95b8dd49633b3d6c
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07981886B2
反応ノート
読み込み中…