Indole → 3-(1H-Indol-3-yl)-2-methyl-2,3-dihydro-isoindol-1-one

HRID 1013179ノート

反応式

HRID 1013179 の反応式
O[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH3:12].[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14]1>>[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4](=[O:11])[N:3]2[CH3:12])=[CH:14]1

参加物

3

反応物 2

HCID 798IndoleHCID 27525883-hydroxy-2-methyl-2,3-dihydro-1H-isoindol-1-one

生成物 1

HCID 533485243-(1H-Indol-3-yl)-2-methyl-2,3-dihydro-isoindol-1-one

実験手順

The product from example 20, step a) (650 mg, 3.98 mmol) and indole (780 mg, 6.67 mmol) were heated (neat) to 180° C. for 30 minutes. The reaction was cooled to rt and the product was recrystallized from ethanol/water to give 452 mg of the sub-title compound as a tan solid.

後処理

  1. customthe product was recrystallized from ethanol/water

出典と根拠

ORDレコード
ord-2d39dbcbab8e423ba7b3b57bd1a20e2a
出典データセット
uspto-grants-2011_07
特許番号
US07981912B2

反応ノート

読み込み中…