4-(Bromomethyl)benzonitrile → {3-[2-(4-Cyano-benzyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methoxy-indol-1-yl}-acetic acid

HRID 1013209

反応式

HRID 1013209 の反応式
C([O:5][C:6](=[O:30])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([CH:19]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[S:21](=[O:29])(=[O:28])[NH:20]2)=[CH:9]1)(C)(C)C.[C:31]([C:33]1[CH:40]=[CH:39][C:36]([CH2:37]Br)=[CH:35][CH:34]=1)#[N:32]>>[C:31]([C:33]1[CH:40]=[CH:39][C:36]([CH2:37][N:20]2[CH:19]([C:10]3[C:11]4[C:16](=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=4)[N:8]([CH2:7][C:6]([OH:5])=[O:30])[CH:9]=3)[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[S:21]2(=[O:29])=[O:28])=[CH:35][CH:34]=1)#[N:32]

参加物

3

反応物 2

HCID 869964-(Bromomethyl)benzonitrileHCID 67316901[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methoxy-indol-1-yl]-acetic acid tert-butyl ester

生成物 1

HCID 59753803{3-[2-(4-Cyano-benzyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methoxy-indol-1-yl}-acetic acid

実験手順

The title compound was prepared by the method described for example 14 using the product from example 4, step c) and 4-cyanobenzyl bromide. MS: ESI (negative): 486 (M−H).

出典と根拠

ORDレコード
ord-0d57555b378d42baa791f6f90198cf65
出典データセット
uspto-grants-2011_07
特許番号
US07981912B2

関連ノート

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