Sodium Bicarbonate → HCID 57652724、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])[CH:8]=[C:9]([N+:11]([O-])=O)[CH:10]=1)=[O:4].C([O-])(O)=O.[Na+]>CCOC(C)=O>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])[CH:8]=[C:9]([NH2:11])[CH:10]=1)=[O:4]参加物
4
実験手順
2′-Methoxy-5-nitro-biphenyl-3-carboxylic acid methyl ester (8.2 g, 28.5 mmol) and SnCl2 dihydrate (35 g) in EtOAc (300 mL) was heated to reflux and stirred for 18 hours, then cooled and stirred at room temperature for 48 hours. Saturated aqueous NaHCO3 was added until the aqueous portion of the mixture reached pH 10. The organic layer was separated, and the aqueous layer was washed with EtOAc. The combined organic layers were washed with water, dried over Na2SO4, filtered and concentrated under reduced pressure to give 7.2 g of 5-amino-2′-methoxy-biphenyl-3-carboxylic acid methyl ester, MS (M+H)=258.