化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | ethyl 3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 67316234 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate | HCID 87353567 | — |
反応手順
To a mixture of EXAMPLE 3A (0.125 g) and triethylamine (0.21 mL) in acetonitrile (3 mL) at 0-5° C. was added methanesulfonyl chloride (0.0404 mL). After 30 minutes, the mixture was concentrated, and the concentrate was purified by flash chromatography on silica gel with 0-30% ethyl acetate/hexanes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07981888B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-f4e23c4e26cc41e6a636336ec866bb2b |
| 出典メモ | uspto-grants-2011_07 |