Hydrochloric Acid → HCID 86635273、化合物
反応式
[CH3:1][P:2]1(=[O:16])[O:7][CH2:6][C:5]2([CH2:12][CH2:11][N:10](C([O-])=O)[CH2:9][CH2:8]2)[CH2:4][O:3]1.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:1][P:2]1(=[O:16])[O:3][CH2:4][C:5]2([CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:6][O:7]1参加物
4
実験手順
3-methyl-2,4-dioxa-9-aza-3-phosphaspiro[5.5]undecane-9-carboxylate 3-oxide (975 mg, 3.19 mmol) was combined with 4.0 M HCl in dioxane (25 mL) and stirred at room temperature for 1 h. The resulting suspension was evaporated to a white solid that was slurried in EtOAc and filtered to give 3-methyl-2,4-dioxa-9-aza-3-phosphaspiro[5.5]undecane 3-oxide hydrochloride as a colorless solid. 1H NMR (DMSO-d6, 600 MHz) δ 8.99 (bs, 2H), 4.21-4.11 (m, 4H), 3.12-3.07 (m, 2H), 3.04-2.99 (m, 2H), 1.82-1.78 (m, 2H), 1.59-1.56 (m, 2H), 1.55 (d, J=17.0 Hz, 3H).
後処理
- customThe resulting suspension was evaporated to a white solid
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-b33bfd8c63374ade8b8c59827aa4fdf8
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07981874B2
反応ノート
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