Quinoline → HCID 178516370、化合物
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:15])=[C:7](C(O)=O)[CH:8]=[N:9]2)=[N:4][CH:3]=1.N1C2C(=CC=CC=2)C=CC=1>CC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:15])=[CH:7][CH:8]=[N:9]2)=[N:4][CH:3]=1参加物
4
実験手順
In a RBF fitted with a reflux condenser, 7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylic acid (1 g, 4 mmol) was added in portions over 10 minutes to stirred refluxing quinoline (50 mL), and the resulting mixture was refluxed for 1 h. The mixture was cooled and diluted with acetone. The precipitate was filtered, washed with water and dried to give 0.8 g of a grey-brown powder. The product was reprecipitated from aq. NaOH with glacial acetic acid to give a white solid.
後処理
- customIn a RBF fitted with a reflux condenser
- temperaturethe resulting mixture was refluxed for 1 h
- temperatureThe mixture was cooled
- filtrationThe precipitate was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-310bbe64cd734a8f9dffaf9bfd3d6ae2
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07981891B2
反応ノート
読み込み中…