Hydrochloric Acid → 2-(aminomethyl)-4-chloro-N,N-dimethylbenzenesulfonamide hydrochloride

HRID 1014003

反応式

HRID 1014003 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:13](=[O:18])(=[O:17])[N:14]([CH3:16])[CH3:15])=[C:6]([CH:12]=1)[CH2:7][NH:8]C(=O)C.Cl>C(O)C>[ClH:1].[NH2:8][CH2:7][C:6]1[CH:12]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[S:13]([N:14]([CH3:16])[CH3:15])(=[O:17])=[O:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66877112N-[5-chloro-2-(dimethylsulfamoyl)benzyl]acetamide

生成物 1

HCID 668781282-(aminomethyl)-4-chloro-N,N-dimethylbenzenesulfonamide hydrochloride収率 185.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(Step 2) To a solution of N-[5-chloro-2-(dimethylsulfamoyl)benzyl]acetamide obtained in Step 1 (1.77 g) in ethanol (20 ml) was added 6N hydrochloric acid (20 ml) at room temperature. The mixture was stirred with heating under reflux for 3 hr, and then stirred overnight at 80° C. The solvent was evaporated under reduced pressure. The residue was collected by filtration, and washed with diethyl ether to give 2-(aminomethyl)-4-chloro-N,N-dimethylbenzenesulfonamide hydrochloride (1.61 g) as a white solid.

後処理

  1. temperaturewith heating
  2. temperatureunder reflux for 3 hr
  3. stirringstirred overnight at 80° C
  4. customThe solvent was evaporated under reduced pressure
  5. filtrationThe residue was collected by filtration
  6. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-88c68a4a495e4d30b025fe19d8298793
出典データセット
uspto-grants-2011_07
特許番号
US07982044B2

関連ノート

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