2-Amino-4-methylbenzamide → 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-4-methylbenzamide

関与物質

反応手順

Using General Protocol II and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (3.0 g, 8.8 mmol) and 2-amino-4-methylbenzamide (2.0 g, 13.2 mmol), 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-4-methylbenzamide was isolated as a white solid (2.81 g, 70% Yield): 1H NMR (400 MHz, DMSO-d6) δ ppm 2.34 (s, 3 H), 2.36 (s, 3 H), 6.65 (d, J=3.84 Hz, 1 H), 6.98 (s, 1 H), 7.47 (d, J=8.05 Hz, 2 H), 7.70 (s, 1 H), 7.74 (s, 1 H), 7.75 (d, J=2.93 Hz, 1 H), 7.98 (d, J=8.42 Hz, 2 H), 8.25 (s, 1 H), 8.33 (s, 1 H), 12.52 (s, 1 H).

情報源と証拠