Phosphorus oxide (P4O10) → 6-Methoxy-1-methyl-3,4-dihydroisoquinoline

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][NH:11][C:12](=O)[CH3:13])[CH:6]=[CH:7][CH:8]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:6](=[CH:7][CH:8]=1)[C:12]([CH3:13])=[N:11][CH2:10][CH2:9]2

参加物

反応物 2

HCID 14812Phosphorus oxide (P4O10)

HCID 10330235N-[2-(3-methoxyphenyl)ethyl]acetamide

生成物 1

HCID 138591866-Methoxy-1-methyl-3,4-dihydroisoquinoline

実験手順

In close analogy to the procedure described above, N-[2-(3-methoxy-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

出典と根拠

ORDレコード: ord-bfdfce78404d467b86e6aeffba28cd6e
出典データセット: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07985753B2

反応ノート

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