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7-Methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol → (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol | HCID 417289 | — |
| 反応物 | 6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid | HCID 33695678 | — |
| 生成物 | (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-methanone | HCID 24810083 | — |
反応手順
In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-ol to provide the title compound as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07985753B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-d01a49c1316b43a2bc1d71981f29967e |
| 出典メモ | uspto-grants-2011_07 |