Bromoacetic Acid → N-Isobutylglycine
反応式
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].Br[CH2:7][C:8]([OH:10])=[O:9]>>[CH2:1]([NH:5][CH2:7][C:8]([OH:10])=[O:9])[CH:2]([CH3:4])[CH3:3]参加物
3
実験手順
Isobutylamine (50 mL, 0.5 mol) was cooled in an ice bath, and bromoacetic acid (6.1 g, 43.9 mmol) added slowly as a solid, insuring that each piece dissolved. After stirring overnight, the excess amine was removed and MeOH was added to the resulting oil. The resulting mixture was concentrated, and repeated using MeOH/HCl. Finally, a white solid was recrystallized from ethanol/ether to provide N-isobutylglycine.HCl (3.95 g, 53.7%).
後処理
- dissolutiondissolved
- customthe excess amine was removed
- additionMeOH was added to the resulting oil
- concentrationThe resulting mixture was concentrated
- customFinally, a white solid was recrystallized from ethanol/ether
出典と根拠
- ORDレコード
- ord-ebc41319e76649ef90442a2e3702c9e1
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07094758B2
反応ノート
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