Hydrochloric Acid → 2-(Ethylsulfanyl)-5-methylbenzonitrile

HRID 1015852ノート

反応式

HRID 1015852 の反応式
F[C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH2:11]([S-:13])[CH3:12].[Na+].Cl>CN(C)C=O>[CH2:11]([S:13][C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5])[CH3:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 27745842-Fluoro-5-methylbenzonitrileHCID 4459711Sodium ethanethiolate

生成物 1

HCID 668771452-(Ethylsulfanyl)-5-methylbenzonitrile収率 87.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

(Step 1) A mixture of 2-fluoro-5-methylbenzonitrile (7.5 g) and sodium ethanethiolate (4.9 g) was stirred in N,N-dimethylformamide (30 ml) at room temperature for 3 hr. The reaction solution was treated with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-(ethylsulfanyl)-5-methylbenzonitrile (8.57 g).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2db38bff7ec14dec8cd024b8c8e282f2
出典データセット
uspto-grants-2011_07
特許番号
US07985863B2

反応ノート

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