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Formic Acid → 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 4-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine | HCID 19693934 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine | HCID 19694031 | — |
反応手順
1 g of 4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine is stirred with 20 ml of formic acid and 5 ml of acetone for 5 hours. The residue which remains after concentrating is purified by chromatography on silica gel using ethyl acetate. 0.3 g=41%; m.p.: 56° to 57° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723450 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-91ac38e1cd644fcdbb0f2037b7004087 |
| 出典メモ | uspto-grants-1998_03 |