1-Nitro-3-[2-(trimethylsilyl)ethynyl]-benzene → 3-[2-(Trimethylsilyl)ethynyl]aniline

HRID 1016386ノート

反応式

HRID 1016386 の反応式
[CH3:1][Si:2]([C:5]#[C:6][C:7]1[CH:8]=[C:9]([N+:13]([O-])=O)[CH:10]=[CH:11][CH:12]=1)([CH3:4])[CH3:3]>CC(O)C>[CH3:1][Si:2]([C:5]#[C:6][C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=1)[NH2:13])([CH3:3])[CH3:4]

参加物

3

反応物 1

HCID 114700401-Nitro-3-[2-(trimethylsilyl)ethynyl]-benzene

生成物 1

HCID 111597943-[2-(Trimethylsilyl)ethynyl]aniline収率 93%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of the nitro compound, 3-[(trimethylsilyl)ethynyl]nitrobenzene, prepared as described above (0.86 g, 3.92 mmol) in 2-propanol (30 mL) was degassed with nitrogen and treated with 5% platinum on alumina (268 mgs). The mixture was shaken under an atmosphere of hydrogen (30 psi) on a Parr shaker apparatus for 22 hours. The reaction mixture was filtered through a short pad of Celite™ (diatamaceous earth) and concentrated by evaporation to give an oil which was dried in vacuo overnight to give the title product (692 mg, 93%) as a yellow brown oil.

後処理

  1. customprepared
  2. customwas degassed with nitrogen
  3. additiontreated with 5% platinum on alumina (268 mgs)
  4. filtrationThe reaction mixture was filtered through a short pad of Celite™ (diatamaceous earth)
  5. concentrationconcentrated by evaporation
  6. customto give an oil which
  7. customwas dried in vacuo overnight

出典と根拠

ORDレコード
ord-e57df4bad2ba405dabf63ba50e98359f
出典データセット
uspto-grants-2002_11
特許番号
US06476040B1

反応ノート

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