Aniline → HCID 178511995、化合物
反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:14]2[C:7]3[N:8]=[C:9]([NH:11][C:12]#[N:13])[S:10][C:6]=3[CH2:5][C:4]=2[CH:3]=1.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:14]2[C:7]3[N:8]=[C:9]([NH:11][C:12]([NH:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[NH:13])[S:10][C:6]=3[CH2:5][C:4]=2[CH:3]=1参加物
4
実験手順
0.26 g of 6-chloro-8H-indeno[1,2-d]thiazol-2-yl-cyanamide is suspended in 10 ml of ethanol at room temperature and, after addition of 0.1 of aniline, heated to reflux for 6 h. The reaction mixture is concentrated in vacuo, and the residue is purified by chromatography on silica gel with 5/1 dichloromethane/ethyl acetate. N-(6-Chloro-8H-indeno[1,2-d]thiazol-2-yl)-N′-phenylguanidine is obtained and melts with decomposition at 210° C.
後処理
- temperatureheated
- temperature