HCID 18407216、化合物 → N-aminoacetyl-N-(2-methoxybenzyl)-2-phenoxyaniline
反応式
[N:1]([CH2:4][C:5]([N:7]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:6])=[N+]=[N-]>CO.[Pt]=O>[NH2:1][CH2:4][C:5]([N:7]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:6]参加物
4
実験手順
To a solution of 647 mg of N-azidoacetyl-N-(2-methoxybenzyl)-2-phenoxyaniline in 7 ml of methanol was added 20 mg of platinum oxide, followed by stirring under a hydrogen atmosphere at room temperature overnight. The reaction mixture was filtered through Celite, and after concentration under reduced pressure, purified by silica gel column chromatography (eluent; ethyl acetate−hexane=1:6) and recrystallized from ethyl acetate-isopropyl ether to give 0.24 g of N-aminoacetyl-N-(2-methoxybenzyl)-2-phenoxyaniline.