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HRID 1016891作成日：2026年10月26日

Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl

https://huagongshe.com/reaction/1016891

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物Diethyl acetamido[(pyridin-3-yl)methyl]propanedioateHCID 13817914—
生成物H-Ala(3-pyridyl)-OMe.2HClHCID 46862166100%

反応手順

Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06476263B1
出典データセットuspto-grants-2002_11
ORD IDord-cf427da310034094a9ed1961e59db6df
出典メモuspto-grants-2002_11