Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate → Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate

HRID 1016896

反応式

[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH:20]([C:28]([O:30][CH3:31])=[O:29])[NH:19]1>CO.C(Cl)Cl>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([N:19]2[CH:20]([C:28]([O:30][CH3:31])=[O:29])[CH2:21][C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:18]2)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

実験手順

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (Aldrich), the title compound was prepared as a solid (mp=37-40° C.). The reaction was monitored by tlc (Rf=0.64 in 10% MeOH/DCM).

出典と根拠

ORDレコード: ord-1fc070bede5b4e00a3436e7863e8fe7d
出典データセット: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06476263B1

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

出典と根拠

関連ノート