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3-Iodo-1-propanol → N-(3,5-Difluorophenylacetyl)-L-alaninyl-L-phenylalanine 3-Iodopropyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Iodo-1-propanol | HCID 69390 | — |
| 反応物 | N-(N-(3,5-difluorophenylacetyl)-L-alaninyl]-L-phenylalanine | HCID 22895006 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | N-(3,5-Difluorophenylacetyl)-L-alaninyl-L-phenylalanine 3-Iodopropyl Ester | HCID 9807836 | — |
反応手順
Following General Procedure B and using N-[N-(3,5-difluorophenylacetyl)-L-alaninyl]-L-phenylalanine (prepared by coupling IV-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-phenylalanine (Aldrich) using General Procedure B) and 3-iodo-1-propanol (Aldrich), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.45 in 5% MeOH/methylene chloride) and the product was purified by preparative tlc using 5% MeOH/methylene chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06476263B1 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-43eb987c3a8b4b8ba735fbb29be63e3c |
| 出典メモ | uspto-grants-2002_11 |