4-(Methanesulfonyl)-3-nitrobenzoic acid → 3-Amino-4-methylsulfonylbenzoic acid

HRID 1017125ノート

反応式

HRID 1017125 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8])([O-])=O.[H][H]>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8]

参加物

5

反応物 2

HCID 27238714-(Methanesulfonyl)-3-nitrobenzoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 227288903-Amino-4-methylsulfonylbenzoic acid

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

0.447 mol of 3-nitro-4-methylsulfonylbenzoic acid was reduced with hydrogen by employing 100 g of Raney nickel in 2.5 l of methanol. The mixture was then heated to reflux and filtered off hot with suction. The filtrate was concentrated.

後処理

  1. temperatureThe mixture was then heated
  2. temperatureto reflux
  3. filtrationfiltered off hot with suction
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-93a46b0ed8fb46ea8f5d878cb19bb8f1
出典データセット
uspto-grants-2002_11
特許番号
US06479436B1

反応ノート

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