Hydrochloric Acid → L-Ribofuranoside, methyl
反応式
Cl.[O:2]=[CH:3][C@H:4]([C@H:6]([C@H:8]([CH2:10][OH:11])[OH:9])[OH:7])[OH:5].[CH3:12]O>>[CH3:12][O:2][CH:3]1[O:9][C@@H:8]([CH2:10][OH:11])[C@H:6]([OH:7])[C@@H:4]1[OH:5]参加物
4
実験手順
A cold solution of dry hydrogen chloride (4;4 g, 0.12 mmol) in methanol (100 mL) was slowly added to the solution of L-(+)-ribose 1 (50 g, 0.33 mole in methanol (1000 mL) at room temperature. After addition, the solution was stirred for 2.5 h and quenched with pyridine (100 mL). The mixture was stirred for 10 min and the solvent was evaporated. The residue was dissolved in pyridine (100 mL) and the resulting solution was concentrated to dryness to give 1-O-methyl-L-ribofuranose 2 as a pale-yellow syrup.
後処理
- additionAfter addition
- customquenched with pyridine (100 mL)
- stirringThe mixture was stirred for 10 min
- customthe solvent was evaporated
- dissolutionThe residue was dissolved in pyridine (100 mL)
- concentrationthe resulting solution was concentrated to dryness
出典と根拠
- ORDレコード
- ord-ae15752a58b34a258a4ede1830ee9e8b
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06479463B1
反応ノート
読み込み中…