tert-butyl (2S)-2-[[4-(dihexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl]amino]-3-(4-hydroxyphenyl)propanoate → HCID 178444782、化合物

HRID 1017506ノート

反応式

HRID 1017506 の反応式
C([O:5][C:6](=[O:37])[C@H:7]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)[NH:8][C:9]1[C:13]([N:14]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:12][S:11](=[O:28])(=[O:27])[N:10]=1)(C)(C)C>C(O)=O>[CH2:15]([N:14]([C:13]1[C:9]([NH:8][C@H:7]([C:6]([OH:37])=[O:5])[CH2:29][C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)=[N:10][S:11](=[O:27])(=[O:28])[N:12]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

3

反応物 1

HCID 178444783tert-butyl (2S)-2-[[4-(dihexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl]amino]-3-(4-hydroxyphenyl)propanoate

生成物 1

HCID 178444782HCID 178444782、化合物収率 98.6%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

N-(4-(N,N-Di-n-hexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl)-L-tyrosine tert-butyl ester (100 mg, 0.19 mmol) was dissolved in formic acid and the mixture stirred at room temperature for 36 hrs. Excess formic acid was removed under reduced pressure to yield N-(4-(N,N-Di-n-hexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl)-L-tyrosine as a white solid (90 mg, 98%). Anal. Calc'd for C23H36N4O5S: C, 57.48; H, 7.55; N, 11.66. Found: C, 57.04; H, 7.23; N, 11.38.

後処理

  1. customExcess formic acid was removed under reduced pressure

出典と根拠

ORDレコード
ord-ad6abf92c21a464ebc73a05d4bd581b5
出典データセット
uspto-grants-2002_11
特許番号
US06479492B1

反応ノート

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