Anthranilamide → 2-(3-methoxyphenyl)quinazolin-4(3H)-one

HRID 1017535ノート

反応式

HRID 1017535 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>CC(N(C)C)=O>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:16]2[NH:6][C:4](=[O:5])[C:3]3[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=3)[N:1]=2)[CH:18]=[CH:19][CH:20]=1

参加物

4

反応物 2

HCID 6942AnthranilamideHCID 115693-Methoxybenzaldehyde

生成物 1

HCID 1354863992-(3-methoxyphenyl)quinazolin-4(3H)-one収率 16.3%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

2-Aminobenzamide (30) (1.0 g, 7.3 mmol) and 3-methoxybenzaldehyde (34) (1.0 g, 7.3 mmol) were heated with stirring in DMAC (20 ml) at 80° C. for 2 h and then poured into ice water (200 ml). The precipitate was collected, washed with water, then dried and purified by column chromatography (silica gel-ethyl acetate/n-hexane) to afford 43 (0.3 g, 15.0%) and 61 (1.4 g, 75.2%) as pale yellow powder. Yield, mp, and spectral data are given in Table 1.

後処理

  1. customThe precipitate was collected
  2. washwashed with water
  3. customdried
  4. custompurified by column chromatography (silica gel-ethyl acetate/n-hexane)

出典と根拠

ORDレコード
ord-e7836cef411d4e559316193769bcd575
出典データセット
uspto-grants-2002_11
特許番号
US06479499B1

反応ノート

読み込み中…