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Sodium Hydroxide → 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4'-Isobutylacetophenone | HCID 93214 | — |
| 反応物 | 1-Benzyl-1H-imidazole-5-carboxaldehyde | HCID 2773239 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one | HCID 53707934 | — |
反応手順
A solution of 4-isobutylacetophenone (2.0 g), 3-benzyl-3H-imidazole-4-carbaldehyde (2.1 g) and 48% sodium hydroxide (0.65 ml) in methanol (20 ml) is heated at 55-60° C. for 6 hours. The reaction mixture is then cooled in an ice bath. The resulting precipitate is filtered, and rinsed with methanol. The yield is 2.5 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06479530B2 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-ac275b4941a24169bdd390a2461dec08 |
| 出典メモ | uspto-grants-2002_11 |