Hydroquinone → 2,5-Dimethyl-4-(2-methoxycarbonyl-ethyl-amino)-1-iodo-benzene

HRID 1017794ノート

反応式

HRID 1017794 の反応式
[CH3:1][C:2]1[CH:8]=[C:7]([I:9])[C:6]([CH3:10])=[CH:5][C:3]=1[NH2:4].[C:11]([O:15][CH3:16])(=[O:14])[CH:12]=[CH2:13].[OH-].C([N+](C)(C)C)C1C=CC=CC=1.C1(C=CC(O)=CC=1)O>>[CH3:10][C:6]1[CH:5]=[C:3]([NH:4][CH2:13][CH2:12][C:11]([O:15][CH3:16])=[O:14])[C:2]([CH3:1])=[CH:8][C:7]=1[I:9]

参加物

5

反応物 4

HCID 785HydroquinoneHCID 7294Methyl AcrylateHCID 66854Benzyltrimethylammonium hydroxideHCID 4770984(4-Iodo-2,5-Dimethylphenyl)Amine

生成物 1

HCID 184051642,5-Dimethyl-4-(2-methoxycarbonyl-ethyl-amino)-1-iodo-benzene

実験手順

15.0 g (0.061 mol) of 2,5-dimethyl-4-iodo-aniline, 55 ml of (0.611 mol) of methyl acrylate, 6 ml of benzyltrimethyl ammonium hydroxide and 0.3 g (3 mmol) of hydroquinone are refluxed for 11 days. Then the excess acrylate is distilled off and the residue is chromatographed on silica gel, eluting with methylene chloride.

後処理

  1. distillationThen the excess acrylate is distilled off
  2. customthe residue is chromatographed on silica gel
  3. washeluting with methylene chloride

出典と根拠

ORDレコード
ord-65e182c3e64e4a9287ee1088b3c7c16d
出典データセット
uspto-grants-2002_11
特許番号
US06479524B1

反応ノート

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