Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 54370741、化合物

HRID 1017994ノート

反応式

HRID 1017994 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=O)=[N:8][CH:9]=1)([O-:3])=[O:2].[C:12]([CH:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13]>C1(C)C=CC=CC=1>[CH2:15]([O:14][C:12](=[O:13])[CH:17]=[CH:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][N:8]=1)[CH3:16]

参加物

4

反応物 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 151455015-Nitropyridine-2-carbaldehyde

生成物 1

HCID 54370741HCID 54370741、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 5-nitro-2-pyridinecarbaldehyde (2.85 g prepared according the procedure described in J. Med. Chem. 1992, 35, 3675) and (carbethoxymethylene)triphenylphosphorane (6.0 g) in dry toluene (120 ml) under nitrogen was stirred and heated at reflux for 6 hours. After standing at room temperature overnight the reaction mixture was evaporated. The residue was subjected to flash chromatography on silica gel eluting with dichloromethane to give the title compound (0.8 g) as a yellow solid.

後処理

  1. customprepared
  2. temperatureheated
  3. temperatureat reflux for 6 hours
  4. customthe reaction mixture was evaporated

出典と根拠

ORDレコード
ord-c3dae748d3bf43a6b4d078efe8ca413c
出典データセット
uspto-grants-2002_11
特許番号
US06479519B1

反応ノート

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