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Methanol → 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2,5-Pyridinedicarboxylic acid | HCID 7493 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
反応手順
A mixture of pyridine-2,5-dicarboxylic acid (8.4 g), methanol (100 ml) and concentrated sulphuric acid (1.7 ml) was heated at reflux for 2 hours, cooled and poured into water (11). The resultant precipitate was collected and recrystallised from ethanol to give the title compound as a white solid, m.p. 222-223° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06479519B1 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-45d8ce59bfa7458b874a7caa5c6d8d35 |
| 出典メモ | uspto-grants-2002_11 |