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Citronellol → 4-Oxo-decanoic Acid 3,7-dimethyl-oct-6-enyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citronellol | HCID 8842 | — |
| 反応物 | 4-Oxo capric acid | HCID 538647 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | 4-Oxo-decanoic Acid 3,7-dimethyl-oct-6-enyl Ester | HCID 53830542 | 91% |
反応手順
A solution of 20.0 g 4-oxo-1-decanoic acid (Synthesis, 1987, 408), 16.8 g citronellol extra and 0.5 g p-toluene-sulfonic acid in 150 ml of cyclohexane was refluxed in a flask equipped with a Dean-Stark trap for 3 hours. Then the reaction mixture was cooled, diluted with ether, washed with saturated NaHCO3 and water. The organic phase was dried, filtered and evaporated to dryness. The resulting oil was purified by chromatography to yield 31.7 g of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06479682B1 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-11630feaa8de4c1b838b6cbecb81d087 |
| 出典メモ | uspto-grants-2002_11 |