Cyclohexylamine → Ethyl 5-amino-6-cyclohexylaminonicotinate

HRID 1018253ノート

反応式

HRID 1018253 の反応式
Cl[C:2]1[C:12]([N+:13]([O-])=O)=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>CS(C)=O.O>[NH2:13][C:12]1[C:2]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[N:3][CH:4]=[C:5]([CH:11]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 2

HCID 7965CyclohexylamineHCID 3784053Ethyl 6-chloro-5-nitronicotinate

生成物 1

HCID 22598045Ethyl 5-amino-6-cyclohexylaminonicotinate収率 74%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Ethyl 6-chloro-5-nitronicotinate (1.00 g, 4.33 mmol) prepared according to A. H. Berrie et al. (J. Chem. Soc. 1951, 2590) was dissolved in DMSO (2 mL) and cyclohexylamine (0.54 g, 5.4 mmol) was added. The mixture was stirred for 1 h at room temperature, diluted with water and the yellow precipitated collected by filtration. The product was washed with water and dried (0.95 g, 74% yield).

後処理

  1. customthe yellow precipitated
  2. filtrationcollected by filtration
  3. washThe product was washed with water
  4. customdried (0.95 g, 74% yield)

出典と根拠

ORDレコード
ord-694c133544054993a29feea37ed77e29
出典データセット
uspto-grants-2002_11
特許番号
US06479508B1

反応ノート

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