Tosylmethyl isocyanide → 1,7,7-Trimethyl-bicyclo[2.2.1]heptane-2-carbonitrile

反応式

[C@:1]12([CH3:11])[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[CH2:4][C:2]2=O.S([CH2:22][N+:23]#[C-])(C1C=CC(C)=CC=1)(=O)=O>>[CH3:11][C:1]12[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[CH2:4][CH:2]2[C:22]#[N:23]

参加物

反応物 2

HCID 161915Tosylmethyl isocyanide

HCID 9543187Npc54264

生成物 1

HCID 184055501,7,7-Trimethyl-bicyclo[2.2.1]heptane-2-carbonitrile

実験手順

(1R)-(+)-Camphor was converted to the nitrile using tosylmethyl isocyanide according to the procedure of O. H. Oldenziel (O. H. Oldenziel, D. van Leusen, and A. M. van Leusen J.Org.Chem. 1977, 42, 3114).

出典と根拠

ORDレコード: ord-ab03afc53d47427c8a72abb2a6f741a2
出典データセット: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06479531B1

反応ノート

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