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Diethylamine → 5-Diethylamino-Furan-2-Carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | 5-Bromofuran-2-carbaldehyde | HCID 600328 | — |
| 触媒 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 5-Diethylamino-Furan-2-Carbaldehyde | HCID 768638 | 85% |
反応手順
5-Bromofuraldehyde was dissolved in dimethylsulfoxide (DMSO) and 1-2 drops of Aliquart 336 (tricaprylylmethylammonium chloride, produced by Aldrich Co.) was added to the solution. 10 Equivalents diethylamine was added to the mixture and refluxed for 4 days. The remaining diethylamine was removed from the reaction mixture and subjected to extraction and column chromatography to obtain 5-diethylamino-2-furaldehyde with a yield of 85%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06482494B2 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-abe686e4d26d4970b2b8826f02866b32 |
| 出典メモ | uspto-grants-2002_11 |