Bromine → HCID 18401372、化合物
反応式
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:14]=[C:13]([O:15][CH:16]([F:18])[F:17])[N:12]([CH3:19])[N:11]=2)=[CH:6][CH:5]=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:14]1[C:10]([C:7]2[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=2)=[N:11][N:12]([CH3:19])[C:13]=1[O:15][CH:16]([F:18])[F:17]参加物
4
実験手順
7.9 g (43 mmol) of bromine were added to a solution of 10.1 g (39 mmol) of 3-(4-chlorophenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 100 ml of carbon tetrachloride, and the mixture was then stirred for 16 h. The solution was then washed with sat. aqueous sodium bicarbonate solution, dried over magnesium sulfate and finally concentrated. Yield: 12.9 g. 1H-NMR (270 MHz, in CDCl3): δ[ppm]=3.84 (s, 3H), 6.69 (t, 1H), 7.40 (d, 2H), 7.81 (d, 2H).
後処理
- washThe solution was then washed with sat. aqueous sodium bicarbonate solution
- dry with materialdried over magnesium sulfate
- concentrationfinally concentrated
出典と根拠
- ORDレコード
- ord-5d02123b22a143e3863af07c489e7422
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06482774B1
反応ノート
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