1-(2-Chloroethyl)piperidine → (Rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-3-(2-piperidin-1-yl-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

HRID 1018596ノート

反応式

HRID 1018596 の反応式
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].Cl[CH2:37][CH2:38][N:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[N:13]([CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]3)[C:12]2=[O:24])[CH2:25][CH2:26]1)=[O:7]

参加物

3

反応物 2

HCID 748271-(2-Chloroethyl)piperidineHCID 10163903(Rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

生成物 1

HCID 10167813(Rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-3-(2-piperidin-1-yl-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

実験手順

The title compound, MS: m/e=610.3 (M+H+), was prepared in accordance with the general method of example 99 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 1-(2-chloroethyl)-piperidine.

出典と根拠

ORDレコード
ord-e8927a571fdf49daaa2216959fa3f278
出典データセット
uspto-grants-2002_11
特許番号
US06482829B2

反応ノート

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