Bromine → N-(4-bromo-3,5-dichlorophenyl)acetamide
反応式
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[C:6]([NH:11][C:12](=[O:14])[CH3:13])[CH:7]=[C:8]([Cl:10])[CH:9]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[Br:1][C:9]1[C:4]([Cl:3])=[CH:5][C:6]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][C:8]=1[Cl:10]参加物
5
反応条件
- 温度
- 50 °C
実験手順
21.3 ml of bromine diluted in 82 ml of acetic acid are added over 6 hours to 84.86 g of N-(3,5-dichlorophenyl)acetamide and 34 g of sodium acetate in 420 ml of acetic acid. After 12 hours at room temperature, the reaction mixture is heated for 5 hours at 50° C. The solvents are evaporated off under reduced pressure. The residue obtained is recrystallized from isopropanol; m.p.=224° C.
後処理
- customThe solvents are evaporated off under reduced pressure
- customThe residue obtained
- customis recrystallized from isopropanol
出典と根拠
- ORDレコード
- ord-4b3540b26be34f8fafeab95b115d5ad6
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06482986B1
反応ノート
読み込み中…