Hydrochloric Acid → 2-Amino-3-cycloheptylpropanoic acid
反応式
C([O:5][C:6](=[O:30])[CH:7]([N:16]=C(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C.Cl>CO>[NH2:16][CH:7]([CH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:6]([OH:30])=[O:5]参加物
4
実験手順
To a solution of 2-(Benzhydrylidene-amino)-3-cycloheptyl-propionic acid tert-butyl ester (1.34 g; 3.31 mmol) in methanol (5 mL) was added 10N HCl solution (15 mL) and the mixture heated to reflux. After 15 h, the mixture was allowed to cool to room temperature and transferred to a separatory funnel and washed with ethyl acetate. The aqueous layer was then neutralized with concentrated ammonium hydroxide solution and the white solid was filtered off and air dried to give 329 mg of 2-Amino-3-cycloheptyl-propionic acid.
後処理
- temperaturethe mixture heated to reflux
- customtransferred to a separatory funnel
- washwashed with ethyl acetate
- filtrationthe white solid was filtered off
- customair dried
出典と根拠
- ORDレコード
- ord-91989a8bdd7242319ae9b2738ae692c3
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06482951B2
反応ノート
読み込み中…