Hydrochloric Acid → 2-Amino-3-cyclooctylpropanoic acid

HRID 1018852ノート

反応式

HRID 1018852 の反応式
C([O:5][C:6](=[O:31])[CH:7]([N:17]=C(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:8][CH:9]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C.Cl>CO.O>[NH2:17][CH:7]([CH2:8][CH:9]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:6]([OH:31])=[O:5]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 865854002-(Benzhydrylidene-amino)-3-cyclooctyl-propionic acid tert-butyl ester

生成物 1

HCID 184021902-Amino-3-cyclooctylpropanoic acid収率 62.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of 2-(Benzhydrylidene-amino)-3-cyclooctyl-propionic acid tert-butyl ester (2.00 g) in methanol (15 mL) was added 10N HCl solution (30 mL) and the mixture heated to reflux. After 20 h, the mixture was allowed to cool to room temperature, diluted with 20 mL of water, transferred to a separatory funnel and washed with ethyl acetate. The aqueous layer was then neutralized with 10N sodium hydroxide solution and further cooled to 0° C. The white solid was filtered off and air dried to give 590 mg of 2-Amino-3-cyclooctyl-propionic acid.

後処理

  1. temperaturethe mixture heated to reflux
  2. customtransferred to a separatory funnel
  3. washwashed with ethyl acetate
  4. temperaturefurther cooled to 0° C
  5. filtrationThe white solid was filtered off
  6. customair dried

出典と根拠

ORDレコード
ord-cc013cc989034414829e764675829ac3
出典データセット
uspto-grants-2002_11
特許番号
US06482951B2

反応ノート

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