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Benzyl Bromide → 1-Benzyl-1H-benzotriazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 反応物 | HCID 178418385 | HCID 178418385 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Benzyl-1H-benzotriazole | HCID 521212 | 57% |
反応手順
To a solution of benzotriazole (1.2 g, 10.1 mmol) in DMF (40 mL) at r.t. was added a solution of 1M t-BuOK in THF (11 mL, 11 mmol). After stirring for 30 min., benzyl bromide (2.0 g, 11.6 mmol) was added. The mixture was further stirred for 1 h, diluted with H2O, extracted with EtOAc. The EtOAc extract was washed with H2O (3×), dried (MgSO4) and concentrated. The residue was swished with hexanes containing small amount of Et2O to give 1.2 g (57%) of title compound as white powders.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06486141B2 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-0d7e2270ce7246869487e599308a828e |
| 出典メモ | uspto-grants-2002_11 |