4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine → 4-(4-Piperidinyl)furo[3,2-c]pyridine

HRID 1018988ノート

反応式

HRID 1018988 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:5][CH2:6][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1

参加物

3

反応物 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

生成物 1

HCID 183997754-(4-Piperidinyl)furo[3,2-c]pyridine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

後処理

  1. temperaturecooled
  2. washwashed with ether
  3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
  4. extractionAfter extraction with dichloromethane
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customto be obtained

出典と根拠

ORDレコード
ord-1a40daa6276a4ceb915aa63c280c7240
出典データセット
uspto-grants-2002_11
特許番号
US06486171B2

反応ノート

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