Carbon tetrabromide → 1H-Indole, 5-bromo-3-(2-bromoethyl)-

HRID 1019006ノート

反応式

HRID 1019006 の反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][CH2:31]O.C(Br)(Br)(Br)[Br:34]>ClCCl>[Br:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][CH2:31][Br:34]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 1229565-Bromo-1H-indole-3-ethanol

生成物 1

HCID 183997061H-Indole, 5-bromo-3-(2-bromoethyl)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 11.5 g of triphenylphosphine in 60 ml of dichloromethane is added to a solution, cooled to 0° C., of 4 g of the compound obtained in Step 1 and 7.5 g of carbon tetrabromide in 100 ml of dichloromethane. After stirring for 48 hours at ambient temperature, the reaction mixture is concentrated in vacuo. The residue obtained is chromatographed on silica gel (dichloromethane/cyclohexane: 80/20), enabling the expected product to be isolated.

後処理

  1. concentrationthe reaction mixture is concentrated in vacuo
  2. customThe residue obtained
  3. customis chromatographed on silica gel (dichloromethane/cyclohexane: 80/20)
  4. customto be isolated

出典と根拠

ORDレコード
ord-7759c659a3cf4ed1aa458bb618732ca1
出典データセット
uspto-grants-2002_11
特許番号
US06486171B2

反応ノート

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