化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 2-chloronicotinate → Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-chloronicotinate | HCID 819931 | — |
| 反応物 | 1-(4-Aminophenyl)-2-methylpropan-1-one | HCID 5151044 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate | HCID 22603050 | 118.9% |
反応手順
A mixture of 1-(4-aminophenyl)-2-methyl-1-propanone (0.0637 mol) and methyl 2-chloro-3-pyridinecarboxylate (0.0637 mol) in 2-methoxyethanol (200 ml) was stirred and refluxed for 90 hours. The mixture was taken up in water and EtOAc and extracted with EtOAc. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 22.6 g of methyl 2[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate (interm. 20).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06486187B1 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-8b32521dad5e43bf90b65ccb18cb8cfd |
| 出典メモ | uspto-grants-2002_11 |