Hydrochloric Acid → 2-Chloro-4,6-di-p-tolyl-1,3,5-triazine

HRID 1019301

反応式

HRID 1019301 の反応式
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[Cl-].[Al+3].[Cl-].[Cl-].Cl.[C:15]1([CH3:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>ClC1C=CC=CC=1Cl>[Cl:3][C:2]1[N:4]=[C:5]([C:18]2[CH:19]=[CH:20][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:7]=[C:8]([C:18]2[CH:19]=[CH:20][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:1]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 7954Cyanuric chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 308512-Chloro-4,6-di-p-tolyl-1,3,5-triazine

試薬・触媒・溶媒 1

HCID 72391,2-Dichlorobenzene溶媒

実験手順

To a stirring mixture of 1 eq of cyanuric chloride and 3 eq of aluminum chloride in o-dichlorobenzene at ice bath temperature was added concentrated HCl (13 wt % based on cyanuric chloride). After 10 minutes, 1.9 eq of toluene was added and the reaction mixture was stirred at ice bath temperature for 30 minutes. The cooling bath was removed, the reaction mixture was allowed to warm to room temperature, and stirred for 21 h. HPLC analysis indicated about 95% cyanuric chloride conversion to 2-chloro-4,6-bis(4-methylphenyl)-1,3,5-triazine and the isomer 2-chloro-4-(4-methylphenyl)-6-(2-methylphenyl)-1,3,5-triazine.

後処理

  1. customThe cooling bath was removed
  2. stirringstirred for 21 h

出典と根拠

ORDレコード
ord-4937ccd740b941f9972c40a4442368b7
出典データセット
uspto-grants-2002_11
特許番号
US06486316B1

関連ノート

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