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Pyrrolidine → 4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2-Chloro-4-methoxy-5-nitropyridine | HCID 44119673 | — |
| 生成物 | 4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine | HCID 57431518 | 46.9% |
反応手順
The method described in Stage 12.1 is followed, starting from 5.4 g (28.64 mmol) of 2-chloro-4-methoxy-5-nitropyridine (WO2003/080610) and 4.53 g (63 mmol) of pyrrolidine. The product obtained is, in this case, purified by chromatography on a silica column, eluting with a mixture of heptane and ethyl acetate. In this way we isolate 3 g of the expected product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08716272B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-13083dc02c234193accf934a72a1ac84 |
| 出典メモ | uspto-grants-2014_05 |