Ethyl Acetate → D-Alloisoleucine, methyl ester
反応式
Cl.[NH2:2][C@@H:3]([C:8]([O:10][CH3:11])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5].C(OCC)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O>[NH2:2][C@@H:3]([C:8]([O:10][CH3:11])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5]参加物
5
実験手順
methyl d-alloisoleucinate hydrochloride (Compound 2) was charged to ethyl acetate. A solution of potassium carbonate in water was then added. The mixture was then stirred vigorously at room temperature for 1 hour. The two layers were separated and the aqueous layer further extracted with ethyl acetate. The organic layers were combined and washed with brine. The organic layers were then concentrated in vacuo and filtered to yield methyl D-alloisoleucinate (Compound 3) as a pale yellow oil.
後処理
- customThe two layers were separated
- extractionthe aqueous layer further extracted with ethyl acetate
- washwashed with brine
- concentrationThe organic layers were then concentrated in vacuo
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-aa5b49271b974048a7b916eb1d69cd63
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716286B2
反応ノート
読み込み中…