Hydrochloric Acid → 1-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-3-yl-urea hydrochloride
反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])[N:22]=[CH:21][N:20]=2)=[O:17])[CH2:10]1)=O)(C)(C)C>ClCCl>[ClH:1].[CH3:32][O:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[C:23]1[N:22]=[CH:21][N:20]=[C:19]([NH:18][C:16]([NH:15][CH:11]2[CH2:12][CH2:13][CH2:14][NH:9][CH2:10]2)=[O:17])[CH:24]=1参加物
4
実験手順
Ethereal HCl (2 ml) was added to a solution of 3-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester (XLII) (0.20 g, 0.47 mmol) in dry dichloromethane (2 ml) and the mixture was stirred for 2 hours at room temperature. The reaction was monitored by TLC. After completion, the solvent was removed from the reaction mixture to provide 0.20 g of 1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-3-yl-urea hydrochloride (compound #23A).