5,5-Dimethylpiperidin-2-one → 5,5-Dimethyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-piperidin-2-one

反応式

[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1([CH3:25])[CH2:23][NH:22][C:21](=[O:24])[CH2:20][CH2:19]1>>[CH3:17][C:18]1([CH3:25])[CH2:23][N:22]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][N:13]=2)[C:21](=[O:24])[CH2:20][CH2:19]1

参加物

反応物 2

HCID 104796605,5-Dimethylpiperidin-2-one

HCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

生成物 1

HCID 529171945,5-Dimethyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-piperidin-2-one

実験手順

The title compound, yellow oil, MS: m/e=319.2 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and 5,5-dimethyl-piperidin-2-one.

出典と根拠

ORDレコード: ord-52c4da5c551443729e053fe897a3c941
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08716316B2

反応ノート

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