Methylamine → N,3-Dimethylpyrazin-2-amine

HRID 1020267ノート

反応式

HRID 1020267 の反応式
Cl[C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 6329MethylamineHCID 66769Pyrazine, 2-chloro-3-methyl-

生成物 1

HCID 44327445N,3-Dimethylpyrazin-2-amine

実験手順

2-chloro-3-methylpyrazine (124 mg, 1.0 mmol) and methylamine (5 mL, 2M solution in THF) was irradiated in a microwave oven at 190° C. for 10 hours. The solution is evaporated and the residue was dissolved in CH2Cl2 (10 mL). It was partitioned with NaOH (1 mL, 5N), dried with NaSO4, filtered and volatiles removed in vacuo to afford N,3-dimethylpyrazin-2-amine. 1H NMR (400 MHz, CDCl3): 7.92 (d, 1H), 7.70 (d, 1H), 4.40 (s, br, 1H), 3.03 (d, 3H), 2.36 (s, 3H). MS (ES+): M/Z 124 (M+1).

後処理

  1. customThe solution is evaporated
  2. dissolutionthe residue was dissolved in CH2Cl2 (10 mL)
  3. customIt was partitioned with NaOH (1 mL, 5N)
  4. dry with materialdried with NaSO4
  5. filtrationfiltered
  6. customvolatiles removed in vacuo

出典と根拠

ORDレコード
ord-a62f1954fc154409a7c090afa8830d36
出典データセット
uspto-grants-2014_05
特許番号
US08716320B2

反応ノート

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