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4-chloropyridine N-oxide → 4-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-chloropyridine N-oxide | HCID 70724 | — |
| 反応物 | 5-Fluoro-2-pyridylbenzylalcohol | HCID 66603372 | — |
| 生成物 | 4-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide | HCID 58092263 | 50.9% |
反応手順
5-Fluoro-2-pyridylbenzylalcohol (3.00 g, 23.6 mmol) and 4-chloropyridine-N-oxide (2.03 g, 15.7 mmol) were reacted according to Example 34 (step a) to provide the title compound (1.76 g, 50%) as a tan solid: 1H NMR (300 MHz, CDCl3) δ 8.48 (s, 1H), 8.12 (d, J=7.7 Hz, 2H), 7.48-7.46 (m, 2H), 6.90 (d, J=7.7 Hz, 2H), 5.20 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08716308B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-8c95283acb4d48f783192ee0bc5c605e |
| 出典メモ | uspto-grants-2014_05 |