Dimethylformamide → 6-Bromo-2-chloroquinoxaline

HRID 1020733ノート

反応式

HRID 1020733 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[N:5]2.CN(C=O)C.O=P(Cl)(Cl)[Cl:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:20])[CH:6]=[N:5]2

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 126863946-Bromo-1,2-dihydroquinoxalin-2-one

生成物 1

HCID 126864086-Bromo-2-chloroquinoxaline

反応条件

温度
50 °C

実験手順

6-bromoquinoxalin-2(1H)-one (9.0 g, 40 mmol) was dissolved in POCl3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50° C. for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.

後処理

  1. customAfter completion of the reaction it
  2. temperaturewas cooled to RT
  3. additionwas poured slowly into ice cold water
  4. filtrationfiltered
  5. customto afford crude product

出典と根拠

ORDレコード
ord-3e5ac592b50a4e9a9d396461501217df
出典データセット
uspto-grants-2014_05
特許番号
US08716473B2

反応ノート

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