Boron tribromide → (R)-3-(1-Aminoethyl)phenol
反応式
C[O:2][C:3]1[CH:4]=[C:5]([C@H:9]([NH2:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)Br>C(Cl)Cl>[NH2:11][C@@H:9]([C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=1)[CH3:10]参加物
4
実験手順
To the solution of (R)-1-(3-Methoxy-phenyl)-ethylamine (0.5 g, 3.31 mmol) in DCM (25 mL) at −78° C. was added 1.0M BBr3 solution in DCM (6.6 mL, 6.62 mmol) dropwise. The solution was warmed to room temperature and the reaction mixture was quenched with methanol (100 mL) and then concentrated in vacuo. This process was repeated until no white fumes were observed upon addition of methanol to afford 3-((R)-1-Amino-ethyl)-phenol as a pale yellow oil (0.51 g) which was used in the next step without further purification.
後処理
- customthe reaction mixture was quenched with methanol (100 mL)
- concentrationconcentrated in vacuo
- additionwere observed upon addition of methanol
出典と根拠
- ORDレコード
- ord-b8976e43bd384dcda29050a7922d5460
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716473B2
反応ノート
読み込み中…